Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock |
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| Authors: | Sang Sik Yun Sung Phil Kim Mi Young Kang Seok Hyun Nam |
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| Institution: | (1) Department of Biological Science, Ajou University, Suwon, 443-749, Republic of Korea;(2) Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, Republic of Korea;(3) Department of Food Science and Nutrition, Kyungpook National University, Daegu, 702-701, Republic of Korea; |
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| Abstract: | The effect of curcumin on lipopolysaccharide/d-galactosamine (LPS/GalN)-induced acute shock model of liver injury was examined in mice. The simultaneous administration
of LPS (5–20 μg kg−1, i.p.) and GalN (700 mg kg−1, i.p.) markedly increased the serum tumor necrosis factor-α (TNF-α), glutamic oxaloacetic transaminase/glutamic pyruvic transaminase (GOT/GPT), and massive hepatic necrosis and inflammation,
leading to 100% lethality. Pre-administration of curcumin (100 mg kg−1, i.p.) 3 h before induction with LPS/GalN imparted a large extent of protection against acute elevation in serum TNF-α and serum GOT/GPT. Hepatic necrosis and lethality caused by LPS/GalN was also greatly reduced by curcumin treatment. The
results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading
TNF-α production, eventually raising the survival rate of septic-shock-induced mice. |
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