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Streamlining genomes: toward the generation of simplified and stabilized microbial systems

Authors:	Audrey Leprince Mark WJ van Passel Vitor AP Martins dos Santos

Institution:	1. Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China;2. Graduate University of the Chinese Academy of Sciences, Beijing 100049, China;3. Shanghai Research and Development Center of Industrial Biotechnology, Shanghai 201201, China;4. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

Abstract:	Download : Download high-res image (115KB) Download : Download full-size image Highlights? Top-down and bottom-up approaches to genome streamlining. ? Computational support for constructing and refactoring streamlined genomes. ? From genome engineering to metabolic reprogramming. ? Perspectives in applied genome engineering.

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