角膜内皮细胞的检测、受损因素及治疗新进展

摘要：角膜内皮细胞(corneal endothelial cells,CECs)通过其屏障作用及离子泵功能维持角膜透明,但年龄、疾病及创伤等因素会使其功能有所降低,导致角膜失代偿、角膜水肿、大泡性角膜病变,甚至视力的丧失。因此,CECs可谓是角膜的"生命"。近年来,CECs的检测方法逐渐新增,并且不同检测指标具有不同意义;导致CECs受损的因素也有所增加,同时CECs损伤后的治疗也逐渐成为近年来的研究热点。早期发现CECs受损、明确病因并进行干预或治疗会减少CECs的损伤,对指导临床工作有重要的意义。本文主要对CECs检测方法及指标、损伤因素及其治疗的最新进展进行了综述。

Recent Progress of the Test Methods, Injury Factors and Therapeutic Strategies for Corneal Endothelial Cells

ABSTRACT: Corneal endothelial cells (CECs) help to maintain corneal transparency via their barrier and ionic "pump" functions. However, this function could be compromised with age and variety of diseases and trauma, leading to corneal decompensation, corneal edema, bullous keratopathy and even loss of visual acuity. Therefore, CECs are regarded as the "life" of the cornea. In recent decades, the number of CECs test methods is increasing, and different CECs test indexes have different meanings; CECs injury factors are also in- creasing. Meanwhile, the treatment of CECs injury has become a hot research topic gradually in recent years. Thus, the early detection of CECs impairment and etiology with early intervention or treatment can reduce the damage of CECs, which has an important significance to guide clinical work. This review elucidates the latest developments in the test methods, damage factors and therapeutic strategies for CECs.