Vasoactive intestinal polypeptide immunoreactivity in the spinal cord of the guinea pig |
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| Authors: | Jochen Triepel Prof. Dr. med. Jürgen Metz Duncan Munroe Stephanie London Stephen Sweriduk Wolf Georg Forssmann |
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| Affiliation: | (1) Department of Anatomy, University of Heidelberg, Heidelberg, Germany;(2) Massachusetts General Hospital, Boston, Massachusetts, USA;(3) Anatomisches Institut, Universität Heidelberg, Im Neuenheimer Feld 307, D-6900 Heidelberg, Germany |
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| Abstract: | Summary The distribution of vasoactive intestinal polypeptide-immunoreactive (VIP-IR) neurons in the lower medulla oblongata and the spinal cord has been analyzed in guinea pigs. This study includes results obtained by colchicine treatment and transection experiments. In the spinal cord, numerous VIP-IR varicosities were observed in the substantia gelatinosa of the columna dorsalis; some were also found in the substantia intermedia and the columna anterior. The spinal VIP-IR nerve fibers were mainly of intraspinal origin and oriented segmentally. VIP-IR nuclei in the spinal cord extended dorsally into corresponding regions of the caudal medulla oblongata, namely from the substantia intermedia medialis and lateralis into the vagus-solitarius complex and from the nucleus spinalis lateralis into the area of the nucleus reticularis lateralis. Additional VIP-IR perikarya were observed in the pars caudalis of the nucleus spinalis nervi trigemini. The VIP-IR nuclei within the caudal medulla oblongata probably form a continuous system with those localized within the spinal cord. They may be involved functionally in the modulation of cardiovascular and respiratory regulation in the guinea pig.Supported by the DFG, Carvas SFB 90 |
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| Keywords: | Vasoactive intestinal polypeptide (VIP) Neuropeptides Immunohistochemistry Spinal cord Guinea pig |
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