Enhancement of tumor cell susceptibility to lymphokine-activated killer cells by treatment with the streptococcal preparation OK432 |
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Authors: | Hiroki Yamaue MD Hiroshi Tanimura Takuya Tsunoda Makoto Iwahashi Masaji Tani Mikiko Tamai Kohei Noguchi Tsukasa Hotta Kazuo Arii |
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Institution: | (1) Department of Gastroenterological Surgery, Wakayama Medical College, 27-Shichibancho, 640 Wakayama, Japan |
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Abstract: | We investigated whether tumor cell lysis by LAK cells was augmented by treatment with OK432in vitro. NK and LAK activity against K562 cells was not enhanced by their treatment with OK432. In contrast, the susceptibility of OK432-treated Daudi and KATO-III cells to lysis by LAK cells was enhanced. Succinate dehydrogenase activity and RNA synthesis were impaired in Daudi and KATO-III cells by treatment with OK432, and moreover the expression of HLA Class I antigen and
2-microglobulin was inhibited in OK432-treated KATO-III cells. Thus, it is suggested that the enhancement of the susceptibility of OK432-treated tumor cells with regard to succinate dehydrogenase activity, RNA synthesis, and HLA Class I antigen expression. |
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Keywords: | HLA class I antigen lymphokine-activated killer cells natural killer cells OK432 RNA synthesis succinate dehydrogenase activity |
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