高密度脂蛋白受体(SR-BI)和胆固醇逆转运

近十几年来对小鼠的B类I型清道夫受体(SRBI)的研究,发现它是一种高亲和力的高密度脂蛋白受体,主要在肝脏和类固醇源性组织中表达。该受体能介导胆固醇酯的选择性吸收,在高密度脂蛋白(HDL)的代谢和胆固醇的“逆转运”中起重要作用。动物实验证明SRBI的表达可减少动脉粥样硬化的发生。如果SRBI对人有相似的作用,它将成为一个好的作用靶点用于临床心脑血管疾病的治疗 。

Development of Studies on SR-BI and Reverse Cholesterol Transport

Several studies in rodent find the scavenger receptor class B,type I (SR-BI) is a high-affinity HDL receptor that mediates selective cholesterol uptake from HDL in cell. It expresses abundantly in the liver and steroidogenic tissues. SR-BI has a influence on HDL metabolism and also plays an important role in reverse cholesterol transport. These indicate that the expression of SR-BI protects the animal against atherosclerosis. If SR-BI has a similar activity in humans, it may become an attractive therapeutic target for atherosclerosis.;