Nonalcoholic steatohepatitis may increase the tendency to development of osteoporosis by decreasing bone mineral density

Osteoporosis is a systemic skeletal disorder characterized by decreased bone mass and deterioration of bony microarchitecture. It is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. Fatty liver disease can range from fatty liver alone (steatosis) to fatty liver associated with inflammation. This state can occur with the use of alcohol (alcohol-related fatty liver) or in the absence of alcohol (NASH). It has been known that liver has important a role in bone metabolism via production of the active vitamin D. Here, we have discussed whether a relationship between NASH and osteoporosis.