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Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling
Authors:Hyowon Choi  Christophe Merceron  Laura Mangiavini  Erin L Seifert  Ernestina Schipani  Irving M Shapiro
Institution:1. Department of Orthopedic Surgery and Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, PA, USA;2. Department of Orthopedic Surgery, University of Michigan, Ann Arbor, MI, USA;3. Inserm, UMRS 791-LIOAD, Center for Osteoarticular and Dental Tissue Engineering, Group STEP ‘Skeletal Tissue Engineering and Physiopathology’, Nantes, France;4. LUNAM, Nantes University, Faculty of Dental Surgery, Nantes, France;5. Department of Orthopedic and Traumatology, Milano-Bicocca University, Monza (MB), Italy;6. Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA;7. Department of Medicine, Division of Endocrinology, University of Michigan, Ann Arbor, MI, USA
Abstract:
Keywords:autophagy  HIF1  hypoxia  intervertebral disc  MTOR-independent autophagy  nucleus pulposus
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