Jurassic PARK2: You eat your mitochondria,and you are what your mitochondria eat |
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| Authors: | Gerald W Dorn II |
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| Institution: | Dept. of Internal Medicine, Center for Pharmacogenomics, Washington University, School of Medicine, St. Louis, MO, USA |
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| Abstract: | Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart. |
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