双歧杆菌三联活菌散对儿童腹型过敏性紫癜患儿肠黏膜屏障的保护作用

目的 探讨双歧杆菌三联活菌散对儿童腹型过敏性紫癜（AP）患者肠黏膜屏障功能的保护作用。方法 选取78例儿童腹型AP患儿，随机分为观察组和对照组各39例。两组患儿均予以抗组胺药、双嘧达莫、西咪替丁、葡萄糖酸钙和维生素C等常规治疗。观察组患儿在此基础上加用双歧杆菌三联活菌散1.0 g/次，3次/d，温开水冲服，两组患儿均连用2周。观察两组患儿治疗前后血清内毒素（LPS）、降钙素原（PCT）和肿瘤坏死因子-α（TNF-α）水平的变化，并比较其治疗效果。结果 治疗2周后，两组患儿血清LPS，PCT和TNF-α水平均较前下降（P<0.05或P<0.01），且观察组患儿下降幅度较对照组更大（P<0.05）。观察组患儿临床总有效率显著高于对照组（χ²=4.09，P<0.05）。结论 双歧杆菌三联活菌散辅助治疗儿童腹型AP患儿的疗效确切，能显著改善患儿的临床症状，加快皮疹的消退，其作用机制可能通过降低血清LPS、PCT和TNF-α水平，减少肠源性内毒素血症的发生，保护肠黏膜屏障功能。

Protective effect of Bifidobacterium Triple Viable on intestinal barrier function in children with abdominal anaphylactoid purpura

Objective To discuss the protective effect of Bifidobacterium Triple Viable on intestinal barrier function of children with abdominal anaphylactoid purpura (AP). Methods 78 children with abdominal AP were randomly divided into observation group (n=39) or control group (n=39). Both groups were given conventional medication including antihistamine drug, Dipyridamole, Cimetidine, Calcium gluconate and Vitamin C, while the observation group was additionally given Bifidobacterium Triple Viable 1.0g tid for 2 weeks. The changes of serum lipopolysaccharide (LPS), procalcitonin (PCT) and tumor necrosis factor-α (TNF-α) were observed in two groups, and the clinical effect were compared. Results After treatment, the levels of serum LPS, PCT and TNF-α of the children in both groups were declined (P<0.05 or P<0.01), and the declining rates in observation group were much higher than those in control group (P<0.05). The total clinical efficiency rate in observation group was much higher than that in control group (χ²=4.09, P<0.05). Conclusion Bifidobacterium Triple Viable has reliable curative effect on abdominal AP in children, which can obviously improve clinical symptoms of children and speed the regression of skin rash. The mechanism of action may relate to the reduction of the levels of serum LPS, PCT and TNF-α, which reduces the occurrence of enterogenous endotoxemia and thus protect intestinal barrier function.