乳酸菌阴道胶囊联合甲硝唑栓对妊娠晚期BV患者阴道乳酸菌及妊娠结局的影响

目的 探讨乳酸菌阴道胶囊联合甲硝唑栓对妊娠晚期细菌性阴道病（BV）患者阴道乳酸菌数量及妊娠结局的影响。方法 选取产科门诊治疗的妊娠晚期BV妇女110例，随机分为观察组和对照组各55例。观察组予以乳酸菌阴道胶囊（1粒/晨，1次/d）联合甲硝唑栓（1粒/晚，1次/d）阴道给药，对照组予以单纯甲硝唑栓阴道给药治疗，用法与用量同观察组，两组疗程均为10 d。治疗结束后1周复诊观察阴道乳酸菌数量，并比较其临床疗效、妊娠结局及阴道假丝酵母菌病（VVC）的发生率。结果 1周后复诊，观察组患者阴道乳酸菌数量多于对照组（χ2=24.44，P0.05）。观察组和对照组分别诱发VVC 2例（3.64%）和8例（14.55 %），观察组VVC发生率低于对照组（χ2=3.96，P<0.05）。结论 妊娠晚期BV患者予以乳酸菌阴道胶囊和甲硝唑栓联合治疗的疗效确切，能增加阴道乳酸菌数量，纠正阴道菌群紊乱，减少VVC的发生率，从而减少早产发生率，改善妊娠结局。

Influence of Lactobacillus Vaginal Capsules combined with Metronidazole Suppositories on lactobacillus and pregnancy outcome of patients with bacterial vaginosis in late pregnancy

Objective To discuss the influence of Lactobacillus Vaginal Capsules combined with Metronidazole Suppositories on vaginal lactobacilli and pregnancy outcome of patients with bacterial vaginosis in late pregnancy．Methods 110 cases of BV in late pregnancy were included and randomly divided into the observation group or control group，with 55 cases in each group．The patients in observation group were given Lactobacillus Vaginal Capsules（qd morning）combined with Metronidazole Suppositories（qd night），while the patients in control group were given Lactobacillus Vaginal Capsules alone；the course of treatment was 10 days．The quantity of vaginal lactobacilli was observed one week after the treatment，and the clinical efficacy，pregnancy outcome and the occurrence rate of VVC were compared between the groups．Results The quantity of vaginal lactobacilli in observation group was much larger than that in control group（χ2=24.44，P0.05）．Two vs eight cases of VVC appeared in observation group（3.64%）vs control group（14.55%）respectively，with significant difference（χ2=3.96，P<0.05）．Conclusion Lactobacillus Vaginal Capsules combined with Metronidazole Suppositories has reliable curative effect on patients with BV in late pregnancy，which can raise the quantity of vaginal lactobacilli，adjust vaginal flora disorder and reduce the incidence of VVC，thus reduce the occurrence rate of premature delivery and improve pregnancy outcome．