Lapachol inhibition of DT-diaphorase (NAD(P)H:quinone dehydrogenase) |
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| Authors: | P C Preusch |
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| Affiliation: | 1. Department of Chemistry, Faculty of Sciences, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, 7915893144, Iran;2. Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;3. Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;1. Anantha Lakshmi Institute of Technology & Sciences, Ananthapuram, India;2. Etcectera Publications, Chesterville, ON, Canada;1. Graduate School of Energy and Environment, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea;2. Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul, 01811, Republic of Korea;1. School of Food Science and Technology, Hunan Agricultural University, Hunan, 410128, PR China;2. State Key Laboratory of Food Science and Technology, Jiangnan University, 214122, Jiangsu, PR China;1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United States;2. Pathology and Laboratory Medicine, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, United States |
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| Abstract: | Lapachol has been found to be a potent inhibitor of the enzyme DT-Diaphorase. Inhibition is competitive versus NADH, Ki = 0.15 microM. Lapachol was not a good substrate for cytochrome P450 reductase, thus inhibition of DT-Diaphorase should not promote its metabolism via radical generating pathways. DT-Diaphorase has been used to test a lapachol affinity chromatography column designed for purification of another coumarin anticoagulant and lapachol sensitive enzyme, vitamin K epoxide reductase. |
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