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Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes |
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| Authors: | Yoo Choung Ryong Yeo In-Sung Park Ko Eun Park Ji Hun Lee Seung Jin Park Won Ho Min Byung-Moo |
| Institution: | aDepartment of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, and BK21 CLS, Seoul National University School of Dentistry, 28 Yeonkun-Dong, Chongno-Ku, Seoul 110-749, Republic of Korea bDepartment of Prosthodontics, Seoul National University School of Dentistry, Seoul 110-749, Republic of Korea cDepartment of Advance Organic Materials and Textile System Engineering, and BK21 FTIT, Chungnam National University, 220 Gung-Dong, Yuseong-Ku, Daejeon 305-764, Republic of Korea dCollege of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea |
| Abstract: | To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds. |
| Keywords: | Electrospinning Nanofibrous scaffolds Human epidermal keratinocytes |
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