Genotoxic effects of thiram evaluated by sister-chromatid exchanges in human lymphocytes |
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| Authors: | M Pienkowska M Zielenska |
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| Institution: | Department of Biochemistry, Warsaw Medical School, Poland. |
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| Abstract: | The purpose of this investigation was to study the genotoxic potential of thiram (CAS No. 137-26-8) using an in vitro sister-chromatid exchange (SCE) assay with human lymphocytes. The results indicate that thiram and its metabolites increase the SCE frequencies 2-fold over those observed in the negative controls. The standard inducers cyclophosphamide and ethyl methanesulfonate increased SCE frequencies 10- and 4-fold, respectively, over untreated levels. |
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