Density and cell cycle dependence of cell surface proteins in hamster fibroblasts |
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Authors: | R O Hynes J M Bye |
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Affiliation: | Department of Tumour Virology Imperial Cancer Research Fund Laboratories P.O. Box 123 44, Lincoln''s Inn Fields, London WC2A 3PX, England |
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Abstract: | The large, external, transformation-sensitive (LETS) glycoprotein of hamster fibroblasts, detected by lactoperoxidase-catalyzed iodination, is shown to vary in its accessibility at the cell surface, depending upon the growth state and position in the cell cycle. High levels correlate with arrest in early G1, and these fall after growth stimulation by serum. Very low levels are detectable on mitotic cells. |
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