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The role of virulence antigens (VW) in the protection of mice againstYersinia pestis infection |
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| Authors: | Akira Wake Tsutomu Maruyama Kazunori Akiyama Makoto Yamamoto |
| Institution: | 1. First Department of Bacteriology, National Institute of Health, 10-35, Kamiosaki 2-chome, Shinagawa-ku, 141, Tokyo, Japan 2. Laboratory of Public Health, Tokyo Metropolitan Research, 24-1, Hyakunincho, 3-chome, Shinjuku-ku, Tokyo, Japan |
| Abstract: | Subcutaneous infection withYersinia enterocolitica harboring plasmid responsible for Ca2+ dependence at 37°C induced cell-mediated protective immunity against a lethal challenge withYersinia pestis; the isogenic derivative strain cured from this plasmid subverted the immunity in mice. This is the first identification of the antigen(s) responsible for the induction of cell-mediated protective immunity against the facultatively intracellular bacteria. |
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