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RIKEN structural genomics beamlines at the SPring-8; high throughput protein crystallography with automated beamline operation |
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| Authors: | Go Ueno Hiroyuki Kanda Raita Hirose Koh Ida Takashi Kumasaka Masaki Yamamoto |
| Institution: | (1) SPring-8/RIKEN, Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan;(2) Present address: Rigaku co., Matsubara, Akishima, Tokyo 196-8666, Japan;(3) PharmAxess, Inc., CAST, Kouto, Kamigori, Ako, Hyogo 678-1205, Japan;(4) Yokohama City University, Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan;(5) Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama, Kanagawa 226-8501, Japan;(6) Present address: Kitasato University, Kitasato, Sagamihara, Kanagawa 228-8555, Japan |
| Abstract: | RIKEN Structural Genomics Beamlines, BL26B1 & BL26B2 at the SPring-8, have been constructed for the structural genomics research. The main feature of the beamline is full automation of the successive data collections to maximize the beam-time efficiency. The beamline optics adopted a standard design commonly used for the SPring-8 bending magnet beamlines. Beamline instruments are operated by centralized control system through the computer network to achieve the automatic operation. The core part of the beamline development is a sample management system composed of sample changer robots for laboratory and beamline, and a networked sample database. BL26B1 has started user operation, and the automatic operation with the sample management system has been implemented at BL26B2. |
| Keywords: | automatic operation high throughput crystallography protein crystallography sample changer structural genomics |
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