Rigorous conformational analysis of right and left DNA helices and junction between them |
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Authors: | V G Tumanyan Yu A Neyfack M K Pirtskhalava J H Männik |
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Institution: | (1) Institute of Molecular Biology, Academy of Sciences of the USSR, 117984 Moscow, USSR |
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Abstract: | On the basis of complete scanning through conformational space of dihedral angles, twelve structural genera were obtained.
Subsequent energy minimization within these genera yielded a limited set of duplexes with stacking: right-handed B-form (Wilkins
type), B2-form (Watson and Crick type) and left-handed Ll-form (Sasisekharan type) and the new L2-form. In the polymeric DNA
only right-handed double-helices are possible, the left-handed helices are forbidden due to poor 1–5 interchain contacts.
In contrast, for short fragments the left- and right-handed helicek have practically the same energies providing some physical
ground for side-by-side form, which biologically is possible as recombination form and may be as replication form. |
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Keywords: | DNA right left conformations polymeric effect |
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