Predictive probability in clinical trials |
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| Authors: | A P Grieve |
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| Affiliation: | Medical Statistics and Data Management, Ciba-Geigy Pharmaceuticals, Horsham, United Kingdom. |
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| Abstract: | ![]()
In a recent paper, Choi and Pepple (1989, Biometrics 45, 317-323) consider the use of predictive probabilities in the monitoring of clinical trials. In particular, they characterise the predictive probability as a "useful conservative measure" for monitoring purposes. In this note the nature and source of this "conservatism" are investigated. |
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