RADIATION EFFECTS ON CELL POPULATIONS IN THE INTESTINAL EPITHELIUM OF MICE AND ITS THEORY |
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| Authors: | F Sato S Muramatsu S Tsuchihashi A Shiragai T Hiraoka T Inada K Kawashima H Matsuzawa W Nakamura E Trucco G A Sacher |
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| Institution: | Division of Radiation Hazards, Chiba, Japan;Physics Division, National Institute of Radiological Sciences, Chiba, Japan;Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, U.S.A. |
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| Abstract: | Mice were exposed to 1000 R of X-rays to their trunks and sacrificed every day up to the tenth day after exposure. Cell counts were made on histological sections of the duodenum. The cell counts in the crypts were reduced to about 50% of the control value on the first day after exposure. The cell counts began to recover on the third day and an overshoot of 170% was observed on the fourth day; thereafter the crypt cell counts tended to return to the control level. The cell counts on the villi reached their minimum value on the third day after exposure. Following an overshoot on the sixth day, the villus cell counts returned to the control level by the tenth day. The above experimental results were analysed using a two-compartment model with a feedback term. A logistic proliferation was assumed for the proliferative crypt cells, while for the postmitotic villus cells the compartment was assumed to be a first in-first out type. The calculated results with this model are in general consistent with the experimental ones. The model seems to possess some essential features of the dynamics of cell renewal in the intestinal mucosa. |
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