Maintenance of membrane integrity and increase of taxanes production in hazel (Corylus avellana L.) cells induced by low-intensity ultrasound |
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| Authors: | Safari Masoumeh Ghanati Faezeh Hajnoruzi Abazar Rezaei Ayatollah Abdolmaleki Parviz Mokhtari-Dizaji Manigeh |
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| Affiliation: | (1) Department of Plant Biology, Faculty of Biological Science, Tarbiat Modares University (TMU), P.O. Box 14115-154, Tehran, Iran;(2) Department of Physics, Faculty of Science, K.N.Toosi University of Technology (KNTU), P.O. Box 15418-49611, Tehran, Iran;(3) Department of Horticulture, Faculty of Agricultural Sciences, Shahed University, 3319118651 Tehran, Iran;(4) Department of Biophysics, Faculty of Biological Science, Tarbiat Modares University (TMU), P.O. Box 14115-154, Tehran, Iran;(5) Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran |
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| Abstract: | Suspension-cultured hazel cells were ultrasonicated at power densities of 4 and 455 mW for 4–40 min. Both treatments stimulated the production of major taxanes: Taxol, 10-deacetylbaccatin, and baccatin III. The highest amounts of these taxanes (0.46, 0.26, and 0.07 mg/l, respectively) were obtained at 8 and 20 min of the treatment at 455 mW. Ultrasound had no adverse effects on cell viability, growth, or membrane integrity. Increased release of taxanes by ultrasound resulted not from increased membrane permeability but more likely from stimulation of taxanes biosynthesis. |
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