Homer proteins: implications for neuropsychiatric disorders |
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| Authors: | Szumlinski Karen K Kalivas Peter W Worley Paul F |
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| Affiliation: | Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA, 93106-9660, USA. szumlinski@psych.ucsb.edu |
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| Abstract: | ![]()
Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia. |
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