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19-Hydroxy-4-androsten-17-one: potential competitive inhibitor of estrogen biosynthesis |
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| Authors: | M Numazawa A Mutsumi K Hoshi R Koike |
| Institution: | Tohoku College of Pharmacy, Sendai, Japan. |
| Abstract: | 3-Deoxy steroids having a 4-ene system were found to be competitive inhibitors of human placental aromatase. 19-Hydroxy-4-androsten-17-one (2) potently inhibits the enzyme with an apparent Ki of 12.5 nM, but does not produce a time-dependent inactivation of the enzyme. |
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