Geographical variability of alpha-1-antitrypsin alleles in China: A study on six Chinese populations |
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| Authors: | Ying Qi-long Zhang Mei-lin Liang Chih-chuan Liu Xiao-po Huang You-wen Wang Rong-xin Zhang Ni-jia Chen Li-chang Chen Luo-fu Yu Ning-chang Muo Xi-ping |
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| Institution: | (1) Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China;(2) Department of Medicine, 303 PLA Hospital, Guangxi, China;(3) Department of Biochemistry, Hainan University School of Medicine, Guangdong, China;(4) Clinical Laboratory, Mudanjiang Medical School Hospital, Heilongjiang, China |
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| Abstract: | Summary Alpha-1-antitrypsin phenotypes of six Chinese Han populations (20°–45°N. latitude) were determined. The frequency of allele M2 increases from North to South China. The north-south change of M2 appears to be mainly at the expense of alleles M1 and M3. Geographical variability of other variants was also observed. In the northern populations, the most common variants are M4 and Etokyo; in the southern populations, Pweishi, a variant which can not be distinguished electrophoretically from Pyasugi. These results form a distribution pattern of alpha-1-antitrypsin alleles in China. |
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