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Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials
Authors:Johnson Paul D  Aristoff Paul A  Zurenko Gary E  Schaadt Ronda D  Yagi Betty H  Ford Charles W  Hamel Judith C  Stapert Douglas  Moerman Judy K
Institution:Discovery-Chemistry, Pharmacia Corporation, 7000 Portage Road, Kalamazoo, MI 49001, USA. paul.d.johnson@pharmacia.com
Abstract:Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.
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