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Joint Multipoint Linkage Analysis of Multivariate Qualitative and Quantitative Traits. II. Alcoholism and Event-Related Potentials
Authors:Jeff T. Williams   Henri Begleiter   Bernice Porjesz   Howard J. Edenberg   Tatiana Foroud   Theodore Reich   Alison Goate   Paul Van?Eerdewegh   Laura Almasy     John Blangero
Affiliation:Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. jeffw@darwin.sfbr.org
Abstract:
The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.
Keywords:
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