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Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online) |
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| Authors: | Chun-Nan Hsu Jin-Mei Lai Chia-Hung Liu Huei-Hun Tseng Chih-Yun Lin Kuan-Ting Lin Hsu-Hua Yeh Ting-Yi Sung Wen-Lian Hsu Li-Jen Su Sheng-An Lee Chang-Han Chen Gen-Cher Lee DT Lee Yow-Ling Shiue Chang-Wei Yeh Chao-Hui Chang Cheng-Yan Kao Chi-Ying F Huang |
| Institution: | 1. Medical Informatics Department, Freiburg University Hospital, Freiburg, Germany 3. Master Program in Health Technology, Pontificial Catholic University of Paraná, Curtiba, Brazil 2. Language and Information Engineering (JULIE) Lab, Jena University, Jena, Germany |
| Abstract: | BackgroundAn adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggregation and containment.ResultsWe demonstrate that the proposed formalism allows to deal consistently with "role propagation along non-taxonomic hierarchies", a problem which had repeatedly been identified as an intricate reasoning problem in biomedical ontologies.ConclusionThe proposed approach seems to be suitable for the redesign of compositional hierarchies in (bio)medical terminology systems which are embedded into the framework of the OBO (Open Biological Ontologies) Relation Ontology and are using knowledge representation languages developed by the Semantic Web community. |
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