Association of functional variants of <Emphasis Type="Italic">PTPN22</Emphasis> and <Emphasis Type="Italic">tp53</Emphasis>in psoriatic arthritis: a case-control study |
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| Authors: | Christopher?Butt Lynette?Peddle Celia?Greenwood Sean?Hamilton Dafna?Gladman Email author" target="_blank">Proton?RahmanEmail author |
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| Institution: | (1) Department of Public Health Sciences, Memorial University of Newfoundland, Hospital for Sick Children, University of Toronto, Toronto, Canada;(2) Department of Public Health Sciences, Genetics and Genomic Biology, Hospital for Sick Children, University of Toronto, Toronto, Canada;(3) University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Canada |
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| Abstract: | Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important
in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these
genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada.
We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted. |
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