|
|||||
|
|
N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging |
|
| Authors: | Shanta R Bhattarai Remant B Kc Sun Y Kim Manju Sharma Myung S Khil Pyoung H Hwang Gyung H Chung Hak Y Kim |
| Affiliation: | 1. Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, 48202, USA 2. Department of Bionanosystem Engineering, Chonbuk National Univiversity, Jeonju, South Korea 3. Deparrtment of Pediatric and Clinical Research Center, School of Medicine, Chonbuk National Univiversity, Jeonju, South Korea 4. Department of Textile Engineering, Chonbuk National Univiversity, Jeonju, South Korea 5. Department of Radiology, School of Medicine, Chonbuk National Univiversity, Jeonju, South Korea |
| Abstract: | This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |