Immunobiological properties of a concanavalin A derivative |
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| Authors: | Sarah Horowitz John M. Mansfield David L. Thomasson Ronald J. Doyle |
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| Affiliation: | Department of Microbiology and Immunology, School of Medicine, University of Louisville, P.O. Box 35260, Louisville, Kentucky 40232 USA |
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| Abstract: | A monovalent subunit of concanavalin A (Con A) was tested for mitogenic effects on murine splenic lymphocytes in vitro. In contrast to the effects of intact Con A, the monovalent derivative was not mitogenic at any concentration tested. Furthermore, prior exposure of splenic lymphocytes to monovalent Con A rendered the cells refractory to stimulation by the unmodified lectin. |
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| Keywords: | To whom requests for reprints should be sent. |
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