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Molecular mimicry in Lyme disease: monoclonal antibody H9724 to b. burgdorferi flagellin specifically detects chaperonin-HSP60 |
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| Authors: | Zhizhong Dai Henry Lackland Stanley Stein Qian Li Robin Radziewicz Stephanie Williams Leonard H Sigal |
| Institution: | 1. Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA;2. Department of Medicine Robert Wood Johnson Medical School-UMDNJ, New Brunswick, NJ, USA;3. Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School-UMDNJ, New Brunswick, NJ, USA |
| Abstract: | A monoclonal antibody (H9724), specific for the 41-kDa flagellar protein of the Lyme disease pathogen Borrelia burgdorferi, cross-reacts with human axons and detects one major protein in human neuroblastoma cell extracts. The homologous cross-reacting protein has now been isolated from calf adrenal and identified as chaperonin-HSP60 by N-terminal sequencing. |
| Keywords: | Lyme disease Molecular mimicry Antibody H9724 Chaperonin HSP60 |
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