EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat |
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| Authors: | Shinya Sato Teiji Tominaga Tomoko Ohnishi S.Tsuyoshi Ohnishi |
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| Affiliation: | 1. Philadelphia Biomedical Research Institute, King of Prussia, PA USA;2. Department of Biochemistry and Biophysics, University of Pennsylvania, School of Medicine, Philadelphia, PA USA |
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| Abstract: | ![]()
The formation of nitric oxide (NO) radicals was demonstrated by electron paramagnetic resonance spectroscopy in the rat during varying degrees of brain ischemia. Diethyldithiocarbamate and Fe-citrate were used as in vivo spin-trapping reagents. The signal of NO spin adducts increased in accordance with the degree of ischemic insults. The formation of NO radicals was inhibited by NG-nitro]l-arginine methyl ester. |
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| Keywords: | Brian ischemia Common carotid occlusion EPR Nitric oxide (NO) Spin-trapping |
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