Search for new cyclic AMP-binding proteins |
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Authors: | Dremier S Kopperud R Doskeland S O Dumont J E Maenhaut C |
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Institution: | IRIBHM, Faculty of Medicine, Free University of Brussels, 808 Route de Lennik, 1070 Brussels, Belgium. sdremier@ulb.ac.be |
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Abstract: | Today, there is evidence that the cAMP-dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP-binding proteins have been recently identified, including some cyclic nucleotide-gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate-binding domains. However, all putative cAMP-binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP-binding property for a protein. |
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Keywords: | Cyclic AMP Cyclic nucleotide monophosphate-binding domain cAMP-binding protein |
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