Epidermal growth factor binding in rat uterus during the peri-implantation period |
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| Authors: | C Chakraborty O W Tawfik S K Dey |
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| Institution: | Department of Gynecology & Obstetrics, University of Kansas Medical Center, Kansas City 66103. |
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| Abstract: | The profile of epidermal growth factor (EGF) binding to uterine membranes of rats on Day 1 through Day 7 of pregnancy was studied. The binding was lowest on Day 1 and increased gradually through the pre- and postimplantation periods. Binding affinity of the Day 7 uterine membranes was considerably higher than that of the Day 1. Apparent affinity constants (Ka) of Day 1 and Day 7 membranes were 0.29 X 10(-8) M and 1.03 X 10(-8) M respectively. To our knowledge, this is the first report of the modulation of EGF binding to uterine membranes by progesterone-estrogen interaction during early pregnancy. |
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