Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1) |
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Authors: | Hwang M G Chung I K Kang B G Cho M H |
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Affiliation: | Department of Biology, Yonsei University, 120-749, Seoul, South Korea. |
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Abstract: | We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo. |
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