| 肝细胞癌中NF-kBp65,VEGF和MMP-9蛋白的表达及其相关性研究 |
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| 引用本文： | 彭颖琼,胡斌,肖伟,周青,鲁猛厚.肝细胞癌中NF-kBp65,VEGF和MMP-9蛋白的表达及其相关性研究[J].现代生物医学进展,2010,10(3). |
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| 作者姓名： | 彭颖琼 胡斌 肖伟 周青 鲁猛厚 |
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| 作者单位： | 1. 中南大学湘雅医院感染科,湖南,长沙,410008
2. 中南大学湘雅医院普通外科,湖南,长沙,410008 |
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| 摘 要： | 目的:探讨肝细胞癌(HCC)组织中NF-kBp65,VEGF和MMP-9的表达及其临床意义。方法:应用免疫组织化学(SP法)检测35例HCC组织,15例癌旁肝组织及10例正常肝组织中NF-kBp65,VEGF和MMP-9蛋白的表达并分析其与临床病理因素的关系。结果:NF-kBp65,VEGF和MMP-9蛋白在HCC组织中高表达率(分别为80%,74%,71%)高于对照组(P<0.01)。NF-kBp65的表达与HCC的Edmondson分级有关,即在Edmondson分级Ⅲ-Ⅳ的癌细胞中NF-kBp65的表达强于Edmondson分级Ⅰ-Ⅱ的(P<0.05);有静脉浸润的HCC组织中NF-kBp65,VEGF和MMP-9的表达高于无静脉浸润者,差异有统计学意义(P<0.05)。但NF-kBp65的表达与年龄,性别,肿瘤大小,AFP水平无关(P>0.05);VEGF和MMP-9的表达与年龄,性别,肿瘤大小,AFP水平,HCC的Edmondson分级无关(P>0.05)。NF-kBp65的表达与VEGF和MMP-9呈正相关(rs1=0.579,P1<0.05;rs2=0.406,P2<0.05)。结论:NF-kB...
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| 关 键 词： | 肝癌 NF-kBp65 VEGF MMP-9 |
Expression of NF-kBp65,VEGF and MMP-9 in hepatocellular carcinoma and their clinical significance |
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| PENG Ying-qiong,HU Bin,XIAO Wei,ZHOU Qing,LU Meng-hou.Expression of NF-kBp65,VEGF and MMP-9 in hepatocellular carcinoma and their clinical significance[J].Progress in Modern Biomedicine,2010,10(3). |
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| Authors: | PENG Ying-qiong HU Bin XIAO Wei ZHOU Qing LU Meng-hou |
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| Institution: | PENG Ying-qiong1,HU Bin2,XIAO Wei1,ZHOU Qing1,LU Meng-hou1 (1 Department of Infectious Diseases,Xiangya Hospital,Central South University,410008,Changsha,China,2 Department of General Surgery,China) |
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| Abstract: | Objective:This study aims to investigate the expression and significance of NF-kBp65,VEGF and MMP-9 in human hepatocellular carcinoma (HCC) progression and prognosis. Methods:The expression of NF-kBp65,VEGF and MMP-9 in 35 cases of HCC, 15 cases of adjacent non-tumor liver tissue, 10 cases of normal liver tissue were studied by immunohistochemical method (SP method), and their relationship to clinicopathological characteristics were analyzed.Results:The high expression rate of NF-kBp65, VEGF and MMP-9 in HC... |
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| Keywords: | hepatocellular carcinoma NF-kBp65 VEGF MMP9 |
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