sIR: siRNA Information Resource,a web-based tool for siRNA sequence design and analysis and an open access siRNA database |
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| Authors: | Jyoti K Shah Harold R Garner David S Shames John D Minna |
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| Affiliation: | (1) Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;(2) Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;(3) Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;(4) Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;(5) Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;(6) Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA;(7) Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA |
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| Abstract: | ![]()
Background RNA interference has revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdown of gene expression. In this report we describe a web-based computational tool, siRNA Information Resource (sIR), which consists of a new open source database that contains validation information about published siRNA sequences and also provides a user-friendly interface to design and analyze siRNA sequences against a chosen target sequence. |
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