Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development |
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Authors: | Avital Regev Shlomit Goldman Eliezer Shalev |
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Institution: | (1) Laboratory for Research in Reproductive Sciences, Department of Obstetrics and Gynecology, Ha'Emek Medical Center, 18101 Afula, Israel;(2) Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel |
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Abstract: | Background Human Plexin-B1 is expressed in two truncated forms. The long form encodes a trans-membranal protein, while the short form,
which is bound to the cell surface and partially secreted, possibly serves as a decoy receptor. Plexin receptors are trans-membrane
proteins. The sema domain, found in the extracellular region, is common to all plexins, semaphorins, and the scatter factor
receptors and is crucial for the biological activity and plexin receptor specificity. Semaphorin-4D/Plexin-B1 binding provides
attractive and repulsive cues for the navigation of axonal growth cones, and new studies suggest that this system also plays
a role in the regulation of the biological functions of endothelial cells, specifically in the control of angiogenesis. In
a previous study, we have demonstrated the expression and possible role of Plexin-B1 in the mouse ovary. The present study
was designed to test the hypothesis that Plexin-B1 effects are mediated by Semaphorin-4D. |
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