Negative-ion fast atom bombardment tandem mass spectrometry for characterization of sulfated unsaturated disaccharides from heparin and heparan sulfate |
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Authors: | Tadashi II Masayuki Kubota Satoshi Okuda Takashi Hirano and Mamoru Ohashi |
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Institution: | (1) Research and Development Laboratories, Soda Aromatic Co., Ltd., Noda-shi, 270-02 Chiba, Japan;(2) Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, 182 Tokyo, Japan;(3) School of Agricultural Science, Nagoya University, Chikusa-ku, 464-01 Nagoya, Japan |
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Abstract: | Negative-ion fast atom bombardment tandem mass spectrometry has been used in the characterization of non-, mono-, di- and trisulfated disaccharides from heparin and heparan sulfate. The positional isomers of the sulfate group of monosulfated disaccharides were distinguished from each other by negative-ion fast atom bombardment tandem mass spectra, which provide an easy way of identifying the positional isomers. This fast atom bombardment collision induced dissociation mass spectrometry/mass spectrometry technique was also applied successfully to the characterization of di- and trisulfated disaccharides.Abbreviations FABMS
fast atom bombardment mass spectrometry
- CID
collision induced dissociation
- MIKE
mass analysed ion kinetic energy
- MS/MS
mass spectrometry/mass spectrometry
- HPLC
high performance liquid chromatography
- UA
d-gluco-4-enepyranosyluronic acid
- CS
chondroitin sulfate
- DS
dermatan sulfate
- HA
hyaluronan
- Hep
heparin
- HS
heparan sulfate
- UA(14) GlcNAc
2-acetamido-2-deoxy-4-O-(-d-gluco-4-enepyranosyluronic acid)-d-glucose
- UA(14)GlcNAc6S
2-acetamido-2-deoxy-4-O-(-d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-glucose
- UA2S(14)GlcNAc
2-acetamido-2-deoxy-4-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-d-glucose
- UA2S(14)GlcNAc6S
2-acetamido-2-deoxy-4-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-glucose
- UA(14)GlcN6S
2-amino-2-deoxy-4-O-(-d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-glucose
- UA2S(14)GlcN
2-amino-2-deoxy-4-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-d-glucose
- UA2S(14)GlcN6S
2-amino-2-deoxy-4-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-glucose
- UA(14)GlcNS
2-deoxy-2-sulfamino-4-O-(-d-gluco-4-enepyranosyluronic acid)-d-glucose
- UA(14)GlcNS6S
2-deoxy-2-sulfamino-4-O-(-d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-glucose
- UA2S(14)GlcNS
2-deoxy-2-sulfamino-4-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-d-glucose
- UA2S(14)GlcNS6S
2-deoxy-2-sulfamino-4-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-glucose
- UA(13)GalNAc
2-acetamido-2-deoxy-3-O-(-d-Gluco-4-enepyranosyluronic acid)-d-galatose
- UA(13)GalNAc4S
2-acetamido-2-deoxy-3-O-(-d-gluco-4-enepyranosyluronic acid)-4-O-sulfo-d-galactose
- UA(13)GalNAc6S
2-acetamido-2-deoxy-3-O-(-d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-galactose
- UA2S(13)GalNAc
2-acetamido-2-deoxy-3-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-d-galactose
- UA2S(13)GalNAc4S
2-acetamido-2-deoxy-3-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-4-O-sulfo-d-galactose
- UA2S(13)GalNAc6S
2-acetamido-2-deoxy-3-O-(2-O-sulfo--d-gluco-4-enepyranosyluronic acid)-6-O-sulfo-d-galactose
- UA(13)GalNAcDiS
2-acetamido-2-deoxy-3-O-(-d-gluco-4-enepyranosyluronic acid)-4,6-di-O-sulfo-d-galactose
- UA(13)GlcNAc
2-acetamido-2-deoxy-3-O-(-d-gluco-4-enepyranosyluronic acid)-d-glucose. |
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Keywords: | unsaturated disaccharide glycosaminoglycan heparin heparan sulfate FABMS CID MS/MS |
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