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A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies
Authors:Gerald C. Tiu  Craig H. Kerr  Craig M. Forester  Pallavi S. Krishnarao  Hannah D. Rosenblatt  Nitin Raj  Travis C. Lantz  Olena Zhulyn  Margot E. Bowen  Leila Shokat  Laura D. Attardi  Davide Ruggero  Maria Barna
Affiliation:1. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA;3. Stanford Medical Scientist Training Program, Stanford University, Stanford, CA 94305, USA;4. Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA;5. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA;6. Division of Pediatric Allergy, Immunology and Bone Marrow Transplantation, University of California, San Francisco, San Francisco, CA 94143, USA;7. Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA;8. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA;9. Children''s Hospital Colorado, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Abstract:
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  • Keywords:ribosomopathy  translational control  p53  ribosome profiling  ribosomal protein haploinsufficiency  4E-BP1  nucleolar stress  limb development
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