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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
Authors:Hiroaki Kasashima  Angeles Duran  Anxo Martinez-Ordoñez  Yuki Nakanishi  Hiroto Kinoshita  Juan F. Linares  Miguel Reina-Campos  Yotaro Kudo  Antoine L’Hermitte  Masakazu Yashiro  Masaichi Ohira  Fei Bao  Daniele V.F. Tauriello  Eduard Batlle  Maria T. Diaz-Meco  Jorge Moscat
Affiliation:1. Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA;2. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA;3. Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka city 545-8585, Japan;4. Department of Pathology, Scripps Clinic, La Jolla, CA 92037, USA;5. Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain;6. Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands;7. Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain;8. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 0828 Barcelona, Spain
Abstract:
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  • Keywords:stroma  cancer-associated fibroblasts  atypical PKCs  PKCz  colorectal cancer  SOX2  SFRP  metastasis  CMS4  TGFβ
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