MAGI: Methylation analysis using genome information |
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| Authors: | Douglas D Baumann RW Doerge |
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| Affiliation: | 1.Department of Mathematics; University of Wisconsin, La Crosse; La Crosse, WI USA;2.Department of Statistics; Purdue University; West Lafayette, IN USA |
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| Abstract: | By incorporating annotation information into the analysis of next-generation sequencing DNA methylation data, we provide an improvement in performance over current testing procedures. Methylation analysis using genome information (MAGI) is applicable for both unreplicated and replicated data, and provides an effective analysis for studies with low sequencing depth. When compared with current tests, the annotation-informed tests provide an increase in statistical power and offer a significance-based interpretation of differential methylation. |
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| Keywords: | annotation informed differential methylation epigenetics epigenomics statistical bioinformatics testing methylation |
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