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The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid |
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| Authors: | Okezie I. Aruoma Barry Halliwell Brigid M. Hoey John Butler |
| Affiliation: | * Department of Biochemistry, University of London King's College Strand Campus, London WC2R 2LS, U.K. † Paterson Institute of Cancer Research, Christie Hospital, Wilmslow Road, Manchester, M20 9BX, U.K. |
| Abstract: | N-acetylcysteine has been widely used as an antioxidant in vivo and in vitro. Its reaction with four oxidant species has therefore been examined. N-acetylcysteine is a powerful scavenger of hypochlorous acid (H---OCl); low concentrations are able to protect 1-antiproteinase against inactivation by HOCl. N-acetylcysteine also reacts with hydroxyl radical with a rate constant of 1.36 × 1010 M−1s−1, as determined by pulse radiolysis. It also reacts slowly with H2O2, but no reaction of N-acetylcysteine with superoxide (O2−) could be detected within the limits of our assay procedures. |
| Keywords: | Free radicals N-acetylcysteine Hydroxyl radical Hypochlorous acid Superoxide Hydrogen peroxide |
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