Polymorphisms of apolipoproteins A-IV and E in a Turkish population living in Germany |
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| Authors: | E Malle K P Pfeiffer K Dugi C Pfeiffer M Glaum M Oezcueruemez H U Kloer A Steinmetz |
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| Institution: | (1) Karl-Franzens University Graz, Institute of Medical Biochemistry, Harrachgasse 21, A-8010 Graz, Austria Tel.: +43-316-380-4208; Fax: +43-316-380-9615; e-mail ernst.malle@kfunigraz.ac.at, AT;(2) Philipps University, Department of Internal Medicine, Division of Endocrinology and Metabolism, Marburg/Lahn, Germany, DE;(3) Leopold-Franzens University Innsbruck, AKH, Institute of Medical Biostatistics and Documentation, Innsbruck, Austria, AT;(4) Justus Liebig University of Giessen, 3rd Department of Internal Medicine, Giessen, Germany, DE |
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| Abstract: | Human apolipoproteins (apo) E and apo A-IV are polymorphic with significantly different allele frequencies among different
ethnic groups. Whereas the variation at the apo E gene locus affects plasma cholesterol levels in all populations studied
so far and is associated with longevity in Caucasians, the influence of the common apo A-IV polymorphism on plasma lipoproteins
has not been unanimously accepted. We have therefore determined the common apo E and apo A-IV polymorphisms by isoelectric
focusing, calculated the respective allele frequencies and studied their effects on plasma lipoproteins in a random sample
of 240 nonrelated Turkish subjects (141 males, 99 females) living in Germany and originating from central and eastern Anatolia.
When compared with the German population and other Caucasians in Europe a prominence of the apo ɛ3 allele frequency (0.885)
was accompanied by a decrease in the frequencies of both the apo ɛ2 allele (0.048) and the apo ɛ4 allele (0.067). Thus, the
Turkish population studied here clustered with populations mainly from southern Europe and Japan, which have low ɛ2 and ɛ4
allele frequencies. Also, the frequency of the A-IV-1 allele was higher (0.967) and that of the A-IV-2 allele lower (0.033)
in the Turkish subjects studied than in other populations. At an average level of total cholesterol of 194.5 ± 45 mg/dl, no
significant influence of the A-IV alleles on plasma lipoproteins was seen. However, apo E and apo B differed significantly
between apo E phenotypes, with high levels of apo E and low levels of cholesterol and apo B in carriers of the ɛ2 allele,
and vice versa for the ɛ4 allele. The average cholesterol excess for the ɛ2 allele was –7.95 mg/dl, for the ɛ3 allele, –1.34,
and for the ɛ4 allele, +14.15 mg/dl. Thus, despite the unusual frequency distribution of the apo E alleles, their effects
on plasma lipoproteins are within the range reported for other populations in Europe.
Received: 10 April 1995 / Revised: 25 March 1996 |
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