Bacteriophage MS2 RNA: A correlation between the stability of the codon: Anticodon interaction and the choice of code words |
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| Authors: | Henri Grosjean David Sankoff Willy Min Jou Walter Fiers R J Cedergren |
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| Institution: | (1) Laboratoire de Chimie Biologique, Université de Bruxelles, 67, rue des Chevaux, B - 1640 Rhode St.-Genèse, Belgium;(2) Centre de Recherches Mathématiques et Département de Biochimie, Université de Montréal, Case postale 6128, Montréal, Québec, Canada;(3) Laboratory of Molecular Biology, University of Ghent, 35, Ledeganckstraat, B - 9000 Ghent, Belgium |
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| Abstract: | Summary The non-random distribution of degenerate code words in Bacteriophage MS2 RNA can be explained partially by considerations of the stability of the codon-anticodon complex in prokaryotic systems. Supporting this hypothesis we note that wobble codons are positively selected in codons having G and/or C in the first two positions. In contrast, wobble codons are statitically less likely in codons composed of A and U in the first two positions. Analyses of nucleotides adjacent to 5 and 3 ends of codons indicate a nonrandom distribution as well. It is thus likely that some elements of RNA evolution are independent of the structural needs of the RNA itself and of the translated protein product.This work was supported by grants from the Belgian Government  Actions concertées - Gekon-certéerde Acties , N.F.W.O. and F.K.F.O. as well as from le Ministère de l'éducation du Québec. A preliminary report of this work was given at the EMBO ribosome workshop, Brussels 1976 |
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| Keywords: | MS2 RNA Codon-anticodon Choice of code words |
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