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The Impact of Hepatitis A Virus Infection on Hepatitis C Virus Infection: A Competitive Exclusion Hypothesis |
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| Authors: | Marcos Amaku Francisco Antonio Bezerra Coutinho Eleazar Chaib Eduardo Massad |
| Institution: | 1. School of Veterinary Medicine, University of S?o Paulo, S?o Paulo, Brazil 2. School of Medicine, University of S?o Paulo, S?o Paulo, Brazil 3. LIM 01-HCFMUSP, S?o Paulo, Brazil 4. London School of Hygiene and Tropical Medicine, London, UK |
| Abstract: | We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings. |
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