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Epoxide hydrolase-catalyzed resolution of ethyl 3-phenylglycidate using whole cells of Pseudomonas sp. |
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| Authors: | Congfa Li Qiao Liu Xin Song Di Ding Aiguo Ji Yinbo Qu |
| Institution: | State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR. China. |
| Abstract: | A Pseudomonas sp. was isolated with enantioselective epoxide hydrolase activity to ethyl 3-phenylglycidate. Cells grown on sucrose and suspended in 10% (v/v) dimethyl formamide as co-solvent produced (2R,3S) ethyl 3-phenylglycidate with 95% ee and 26% yield in 12 h from 0.2% (w/v) of the racemate. |
| Keywords: | enantioselectivity epoxide hydrolase ethyl 3-phenylglycidate kinetic resolution |
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