Cytotoxic response against human immunodeficiency virus (HIV): control with suppressor factor] |
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| Authors: | B Sadat-Sowti P Debré B Autran |
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| Affiliation: | Laboratoire d'Immunologie tissulaire et cellulaire, CERVI, Paris. |
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| Abstract: | We report a new suppressor function of CD8+ CD57+ lymphocytes from HIV-seropositive patients recipients, on the cytolytic activity of allospecific CTL, NK and LAK cells. This inhibitory effect is mediated by a non-antigen specific soluble factor distinct from PGE2, TGF beta and TNF alpha and beta. Biochemical characterization indicates that the CD8+ CD57+ inhibitory activity: 1) is heat and trypsin resistant but remains sensitive to pronase E hydrolyse, 2) specifically bind to concanavalin A-sepharose column, 3) is mediated by a 20-30 kdaltons glycoprotein. |
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