Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene |
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| Authors: | Kemppainen Robert J Cox Elaine Behrend Ellen N Brogan Michele D Ammons Jessica M |
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| Affiliation: | Department of Anatomy, Physiology and Pharmacology, Auburn University, College of Veterinary Medicine, 213 Greene Hall, Auburn, AL 36849, USA. kempprj@vetmed.auburn.edu |
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| Abstract: | ![]()
The Dexras1 gene responds to glucocorticoids with a rapid and profound induction. A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. This element conferred rapid glucocorticoid responsiveness when inserted into a homologous promoter-driven luciferase reporter. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness. |
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