腹腔镜与开腹手术对胃癌根治术患者TNF-alpha和IL-6 水平的影响研究

目的:探讨腹腔镜与开腹手术对胃癌根治术患者肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响.方法:选取自2011年3月至2013年5月期间来我院就医并行胃癌根治术的72例胃癌患者作为研究对象.并将所有患者随机平均分成腹腔镜组和传统开腹组各36例.其中,腹腔镜组行腹腔镜辅助下胃癌根治术,传统开腹组行传统开腹胃癌根治术.比较两组手术时间、术中出血量、肛门排气时间及住院时间;比较两组患者术前及术后血清TNF-α和IL-6水平.结果:腹腔镜组术中出血量、肛门排气时间及住院时间均明显低于对照组(P＜0.05)腹腔镜组术后TNF-α和IL-6水平明显低于开腹组(P＜0.05),两组比较有显著性差异(P＜0.05).结论:腹腔镜辅助下胃癌根治术较传统开腹胃癌根治术术后血清TNF-α和IL-6水平低,对机体免疫功能影响较小,可减少患者术后感染机会,值得在临床中推广应用.

Effect of Laparoscopic Surgery and Open Surgical Resection on TNF-alpha and IL-6 Levels in Patients with Radical Gastrectomy

Objective:To investigate Effect of Laparoscopic Surgery and Open Surgical Resection on TNF-alpha and IL-6 Levels in Patients with Radical Gastrectomy.Methods:72 patients with radical gastrectomy from March 2011 to May 2013 in our hospital were randomly divided into conventional open surgical group and laparoscopic surgical group, and 36 cases were in each group. The laparoscopic group underwent laparoscopic-assisted laparoscopic radical gastrectomy while the conventional open surgical group was given conventional open gastrectomy. Surgery time, blood loss, anal exhaust time, hospital stay time, preoperative and postoperative serum TNF-alpha and IL-6 levels were compared between the two groups.Results:The blood loss, anal exhaust time and hospital stay time of the laparoscopic surgical group were significantly less than those of the control group (P<0.05); the TNF-alpha and IL-6 levels of laparoscopic group were significantly lower than those of the conventional open surgical group, the difference was significant (P<0.05).Conclusion:The serum TNF-alpha and IL-6 levels of laparoscopic-assisted radical gastrectomy are lower compared with conventional open surgery postoperativ, and it exerts less impact on immune function, and can reduce the chances of infection, thus it is worth promoting in clinic.